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对２７例表浅膀胱癌术后ＢＣＧ膀胱灌注前后膀胱壁Ｔ＿３、Ｔ＿４、Ｔ＿８、ＩＬ－２Ｒ表达及尿液中肿瘤坏死因子（ＴＮＦ）含量进行了研究。结果表明，ＢＣＧ膀胱灌注后膀胱壁大量淋巴细胞浸润，Ｔ＿４／Ｔ＿８比值由灌注前０．６上升至１．９，２０例患者膀胱壁形成淋巴肉芽肿，粘膜下散在淋巴细胞表面广泛表达ＩＬ－２Ｒ，但肉芽肿淋巴细胞表面几乎不表达ＩＬ－２Ｒ。灌注后２４小时尿液中ＴＮＦ含量显著升高（Ｐ＜０．０１），实验结果提示：Ｔ＿４、巨噬细胞在ＢＣＧ抗肿瘤效应中起着非常重要的作用。
The expression of T_3, T_4, T_8 and IL-2R in bladder wall and the content of tumor necrosis factor (TNF) in urine of 27 cases of superficial bladder cancer before and after perfusion of BCG were studied. The results showed that a large number of lymphocytes infiltrated into the bladder wall after BCG instillation, the ratio of T_4 / T_8 increased from 0.6 before perfusion to 1.9, and 20 cases formed lymphatic granuloma in the bladder wall. The submucosal scattered lymphocytes expressed IL- 2R, but almost no IL-2R was expressed on the surface of granulomatous lymphocytes. The content of TNF in urine increased significantly 24 hours after perfusion (P <0.01), and the results showed that T 4 and macrophages played a very important role in anti-tumor effect of BCG.