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目的比较埃索美拉唑联合西沙必利与奥美拉唑联合西沙必利治疗反流性食管炎的疗效。方法将360例内镜下见食管黏膜有明确损伤的患者分为3组(每组120例),埃索美拉唑+西沙必利(A组),奥美拉唑+西沙必利(B组);对照组(C组)口服雷尼替丁和硫糖铝。疗程均为6周,观察症状变化及内镜下黏膜修复情况。结果A组和B组内镜下食管炎改善总有效率分别为94.2%和89.2%,而对照C组总有效率73.3%,与A和B两组比较有显著差异(P<0.05);三组在症状改善总有效率分别为96.7%、84.2和70.8%。A组与B、C组比较均存在显著性差异P<0.05。结论埃索美拉唑联合西沙必利较奥美拉唑联合西沙必利治疗RE疗效更显著,能迅速改善症状,内镜下愈合率高,是治疗RE更有效的药物。
Objective To compare the efficacy of esomeprazole combined with cisapride and omeprazole in combination with cisapride in the treatment of reflux esophagitis. Methods Three hundred and six patients with definite injury of esophageal mucosa under endoscopy were divided into three groups (120 in each group), esomeprazole + cisapride (group A), omeprazole + cisapride (B Group); control group (group C) oral ranitidine and sucralfate. The course of treatment was 6 weeks, observed changes in symptoms and endoscopic mucosal repair. Results The total effective rates of endoscopic esophagitis in group A and group B were 94.2% and 89.2%, respectively, while those in control group C were 73.3%, which were significantly different from those in group A and B (P <0.05) The total effective rate of group improvement was 96.7%, 84.2 and 70.8% respectively. There was significant difference between group A and group B and C (P <0.05). Conclusion Esomeprazole combined with cisapride than omeprazole combined with cisapride in the treatment of RE more significant effect, can quickly improve the symptoms, high healing rate of endoscopic treatment of RE more effective drugs.