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非程序DNA合成试验已被用作检测化学物质的致癌性/诱变性,筛选化学致癌物的一项重要参考指标。本文用人外周血淋巴细胞的UDS试验对受污染河水及其沿岸饮用井水有机提取物的致突变性进行了检测。结果表明河水及井水有机提取物均可诱发CPM值的明显增加,用不同浓度按等比级数剂量进行试呈明显的剂量反应关系,提示该河水与井水有机提取物均有直接损伤DNA的能力,从而诱发突变。
Non-programmed DNA synthesis assays have been used as an important reference for detecting carcinogenicity / mutagenicity of chemical substances and for screening chemical carcinogens. In this paper, the UDS test of human peripheral blood lymphocytes was used to detect the mutagenicity of organic extracts of contaminated river water and its drinking water along the coast. The results showed that river water and well water organic extract could induce a significant increase in CPM value, with different concentrations of equal-dose dose test showed significant dose-response relationship, suggesting that the river water and well water organic extracts have direct DNA damage The ability to induce mutations.