论文部分内容阅读
目的 探讨二硫化碳（ Ｃ Ｓ２） 对作业女工孕早期胚胎发育的影响。方法 采用早早孕丢失为观察指标进行了研究，在观察期间共征集到１３９ 名欲要生育的女工，于每个月经周期２１ 天开始收集晨尿及隔日晨尿，至月经来潮或临床确诊妊娠止，共３４０ 个月经周期，２ ０４５ 份尿样，单克隆酶免方法定量测定尿样中绒毛膜促性腺激素含量。结果 接触组女工早早孕丢失率为４８ ．７ ％ ，明显高于对照组（２６ ．３ ％ ， Ｐ＝ ０ ．００４ １） 。夫妻双方均接触 Ｃ Ｓ２ 时，早早孕丢失率明显升高（ Ｐ＝ ０ ．００７ ４） 。作业地点 Ｃ Ｓ２浓度与早早孕丢失率相关（ ｒ ＝ ０ ．９９９ ， Ｐ＝ ０ ．００１） 。结论 接触 Ｃ Ｓ２ 的女工早早孕丢失的危险性升高， Ｃ Ｓ２ 浓度与早早孕丢失率之间有明显的剂量反应关系。
Objective To investigate the effect of carbon disulfide (C S2) on the development of embryos during early pregnancy in female workers. Methods The early pregnancy loss as an indicator was studied during the observation period to collect a total of 139 women who want to give birth in each menstrual cycle 21 days to collect morning urine and morning urine, menstrual cramps or clinically diagnosed pregnancy only , A total of 340 menstrual cycles, 2 045 urine samples, monoclonal enzyme-free method for quantitative determination of human chorionic gonadotropin content. Results The early pregnancy loss rate of women workers in the contact group was 48. 7%, significantly higher than the control group (26.3%, P = 0.0041). When both spouses were exposed to C S2, the rate of early pregnancy loss was significantly increased (P = .007 4). The concentration of CS2 at the site of operation was associated with early pregnancy loss (r = 0.999, P = .001). Conclusion The female workers exposed to C S2 have a higher risk of early pregnancy loss, and there is a clear dose-response relationship between C S2 concentration and early pregnancy loss rate.