论文部分内容阅读
毒性休克综合征毒素-1(TSST-1)是由金黄色葡萄球菌产生的一种致热外毒素,它能引起毒性休克综合征。该病的特点是发热、低血压、皮肤脱落以及多系统功能紊乱。TSST-1同其他细菌超抗原一样,是一种较强的T细胞激活剂。这些抗原直接与抗原呈递细胞上的MHC Ⅱ类分子相结合,并通过TCR-βⅤ区刺激T细胞,致产生过多的细胞因子而引起中毒性休克。这些细胞因子包括TNF-α、IFN-γ、IL-1以及具有免疫增强效应和致病的炎症介质。 Th细胞(CD4)可分Th1细胞和Th2两种亚群,Th1细胞产生的IFN-γ和IL-2在细
Toxic Shock Syndrome Toxin-1 (TSST-1) is a pyrogenic exotoxin produced by Staphylococcus aureus that causes toxic shock syndrome. The disease is characterized by fever, hypotension, exfoliation and multiple system disorders. Like other bacterial superantigens, TSST-1 is a potent T-cell activator. These antigens bind directly to MHC class II molecules on antigen-presenting cells and stimulate T cells via the TCR-β V region, resulting in excessive cytokine production causing toxic shock. These cytokines include TNF-α, IFN-γ, IL-1 and inflammatory mediators with immune-enhancing effects and pathogenicity. Th cells (CD4) can be divided Th1 cells and Th2 two subgroups, Th1 cells produce IFN-γ and IL-2 in the fine