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目的了解复发性阿弗他溃疡(RAU)患者溃疡期和间歇期唾液中肝细胞生长因子(HGF)质量浓度的差异,并探讨其在RAU发生及愈合中的作用。方法选择30例轻型RAU患者分别在溃疡期和间歇期(溃疡愈合后1周内)采集其唾液,同期选择30例健康成人采集其唾液,采用酶联免疫吸附法(ELISA)检测三组唾液样本中HGF的质量浓度。结果 RAU患者溃疡期唾液HGF质量浓度低于间歇期和对照组(F=12.63,P<0.01),间歇期唾液HGF质量浓度高于对照组(LSD-t检验P<0.05)。结论 RAU的发生可能与唾液中HGF质量浓度降低有关,其自愈可能与HGF浓度升高有关。
Objective To investigate the difference of the concentration of hepatocyte growth factor (HGF) in saliva from patients with recurrent aphthous ulcer (RAU) during the ulcer and intermittent periods and to explore its role in the occurrence and healing of RAU. Methods Thirty patients with mild RAU were selected for saliva collection in ulcer and intermittent phases (within 1 week after ulcer healing), 30 healthy adults were selected to collect their saliva at the same period, and three saliva samples were detected by enzyme-linked immunosorbent assay (ELISA) In the mass concentration of HGF. Results The concentration of salivary HGF in ulcer stage was lower in patients with RAU than that in intermittent and control groups (F = 12.63, P <0.01). The concentration of saliva HGF in intermittent salivary glands was higher than that in control group (LSD-t test P <0.05). Conclusion The occurrence of RAU may be related to the decrease of HGF concentration in saliva, which may be related to the increase of HGF concentration.