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去年12月13日至14日召开了青心酮鉴定会。通过了技术鉴定。青心酮是秃毛冬青叶的有效成分之一。秃毛冬青系冬青科植物,民间以其叶入药,有活血通脉、消肿止痛作用。中国人民解放军157医院曾用秃毛冬青叶的粗制剂“心舒宁”治疗冠心病,获得初步疗效。1975年10月至1976年11月,北京制药工业研究所与该医院协作,对秃毛冬青叶治疗冠心病的有效成分进行深入研究。经药理筛选试验和临床观察结果表明,其酚性部分具有明显的生理活性。由此对酚性部分作进一步分离,得到8个单体。其中Ⅱ号结晶生理性最强,测定其化学结构为3,4-二羟基苯乙酮,并进行了化学合成。合成品与天然结晶理化性质完全一致,定名青心酮。经北京15个医疗单位282例临床试用,其中107例采用随机双盲法进行疗效
The Qingxin ketone appraisal meeting was held from December 13 to 14 last year. Passed technical appraisal. Qingxin ketone is one of the active ingredients of bald holly leaves. Bald holly is a family of holly plants. Folks use their leaves as medicine, which has the function of promoting blood circulation, reducing swelling, and relieving pain. The 157th Hospital of the Chinese People’s Liberation Army once used the rough preparation of the bald holly leaf “Xinshuning” to treat coronary heart disease, and obtained preliminary results. From October 1975 to November 1976, the Beijing Institute of Pharmaceutical Industry cooperated with the hospital to conduct in-depth studies on the active ingredients of the treatment of coronary heart disease with bald holly leaf. The pharmacological screening test and clinical observation results showed that the phenolic part has obvious physiological activity. The phenolic moiety was thus further separated to give 8 monomers. Among them, crystal No. II has the strongest physiology, its chemical structure was determined to be 3,4-dihydroxyacetophenone, and it was chemically synthesized. The physicochemical properties of the synthetic product and the natural crystal are completely consistent, and the name is Qingxin ketone. After clinical trials in 282 cases in 15 medical units in Beijing, 107 cases were randomized and double-blind