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目的研究血清尿酸与胰岛素抵抗的关系。方法利用1999年在北京市自然人群中通过分层随机抽样获得的数据,以胰岛素敏感指数(IAI)作为评价胰岛素敏感性的指标,在年龄为35～64岁的1056人中分析了血清尿酸与胰岛素敏感指数及胰岛素抵抗的关系。结果(1)IAI 的中位数水平随血清尿酸水平的升高而降低,血清尿酸水平最高组中 IAI 的中位数为0.027,比最低组低32.5%。(2)胰岛素抵抗的患病率随血清尿酸水平的升高而增加(x~2=17.475,P<0.001),血清尿酸水平最高组中胰岛素抵抗患病率为33.9%,是最低组的2.46倍。(3)采用多因素 Logistic 回归分析调整了性别、年龄和代谢综合征的主要成分后,血清尿酸和胰岛素抵抗的关联仍存在(OR=1.201,P=0.004)。结论血清尿酸与胰岛素抵抗存在关联,并独立于性别、年龄和代谢综合征中的主要成分。应重视尿酸代谢异常在代谢综合征发生及发展中的作用。
Objective To study the relationship between serum uric acid and insulin resistance. Methods Using data from stratified random sampling in natural populations in Beijing in 1999 and using insulin sensitivity index (IAI) as an index to evaluate insulin sensitivity, serum uric acid and serum uric acid were analyzed in 1056 aged 35-64 years Insulin sensitivity index and insulin resistance. Results (1) The median IAI level decreased with the increase of serum uric acid level. The median IAI in the highest serum uric acid level was 0.027, 32.5% lower than the lowest level. (2) The prevalence of insulin resistance increased with the rise of serum uric acid level (x ~ 2 = 17.475, P <0.001). The prevalence of insulin resistance in the highest serum uric acid level was 33.9%, which was the lowest of 2.46 Times (3) After adjusted the main components of sex, age and metabolic syndrome by multivariate logistic regression analysis, the relationship between serum uric acid and insulin resistance still exists (OR = 1.201, P = 0.004). Conclusions Serum uric acid is associated with insulin resistance and independent of gender, age, and major component of the metabolic syndrome. Should pay attention to abnormal uric acid metabolism in the occurrence and development of metabolic syndrome.