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目的探讨HPV检测在宫颈病变诊断及CIN术后随访中的价值。方法回顾性分析了2009年5月~2013年5月入住本院120例宫颈病变及CIN患者的临床资料,对其进行术后随访,分析术后1、6、12与24个月HR-HPV-DNA检测预测病变残留情况。结果术后1、6、12与24个月HR-HPV-DNA检测预测病变残留分别为21.6%、30.8%、55.0%及41.6%,阴性预测值均为100%;50例行宫颈锥切患者术后1、6、12与24个月HPV阴性率分别为66.0%、68.0%、88.0%及86.0%;46例行全子宫切除患者术后1、6、12与24个月HPV阴性率分别为60.8%、69.5%、73.9%及80.4%;24例广泛子宫切除组1、6、12与24个月HPV阴性率分别为54.1%、70.8%、79.1%及62.5%。结论 HPV检测在宫颈病变诊断及CIN临床治疗后的随访中有一定的重要性;根据不同级别宫颈病变所采用的术式均能有效清除HPV,但宫颈病变即CIN转阴需要一段时间,治疗后仍阳性者,应及时加强治疗。
Objective To investigate the value of HPV detection in the diagnosis of cervical lesions and follow-up after CIN. Methods The clinical data of 120 patients with cervical lesions and CIN admitted to our hospital from May 2009 to May 2013 were retrospectively analyzed. The patients were followed up and analyzed the HR-HPV at 1, 6, 12 and 24 months after operation DNA test to predict residual disease. Results The predicted residual lesions of HR-HPV-DNA test at 1, 6, 12 and 24 months after operation were 21.6%, 30.8%, 55.0% and 41.6%, respectively. The negative predictive values were 100% The HPV negative rates at 1, 6, 12 and 24 months after operation were 66.0%, 68.0%, 88.0% and 86.0%, respectively. The HPV-negative rates at 1, 6, 12 and 24 months after operation Were 60.8%, 69.5%, 73.9% and 80.4% respectively. The HPV negative rates at 1, 6, 12 and 24 months were 54.1%, 70.8%, 79.1% and 62.5% in 24 cases of extensive hysterectomy respectively. Conclusion The HPV test has certain importance in the diagnosis of cervical lesions and follow-up after CIN clinical treatment. HPV can be effectively removed according to the surgical procedures adopted in different grades of cervical lesions. However, it takes time for cervical lesions to be negative after CIN treatment. After treatment Still positive, should be promptly strengthened treatment.