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应用ＨＰＬＣ－ＥＣＤ测定ＤＡ更新率（ＤＯＰＡＣ／ＤＡ），证明（－）ＳＰＤ对黑质－纹状体、中脑－边缘系统、下丘脑－垂体ＤＡ神经系统的ＤＡ含量影响不明显，却显著增加ＤＯＰＡＣ含量，并显著加强这些脑区的ＤＡ更新率，这可能是通过末梢的ＤＡ自身受体实现的。但（－）ＳＰＤ既不显著影响中脑－前额叶和中脑－扣带回的ＤＡ含量，也不影响其中ＤＯＰＡＣ含量，表明它不影响这些脑区ＤＡ更新率。这可能是由于皮层ＤＡ系统神经末梢缺乏ＤＡ自身受体的缘故。
The DA update rate (DOPAC / DA) was measured by HPLC-ECD. The results showed that (-) SPD had no obvious effect on the DA content in substantia nigra and striatum, midbrain-limbic system and hypothalamic-pituitary DA neurological system, DOPAC content, and significantly enhance the DA update rate in these brain regions, probably through the peripheral DA autoreceptors. However, (-) SPD did not significantly affect the midbrain - prefrontal and midbrain - cingulate DA content nor did it affect the DOPAC content, suggesting that it does not affect DA turnover rates in these brain regions. This may be due to the lack of DA autoreceptors in the cortical DA system nerve endings.