铱催化不饱和杂环羧酸的不对称氢化反应研究

• 出 处: 有机化学
• 发表日期: 2013年07期
• 关键词: 氢化反应 不对称 催化氢化 不饱和羧酸 对映选择性 手性催化剂 链状 手性药物 合成中间体 天然产物

手性杂环羧酸是很多手性药物的重要合成中间体,也是多种天然产物的核心骨架.对不饱和杂环羧酸的不对称催化氢化是合成手性杂环羧酸最高效的方法之一.虽然人们已经发展出很多高效的手性催化剂实现了多种链状不饱和羧酸的高对映选择性氢化反应,但是对环状不饱和羧酸的不对称催化氢化很少有成功的例子报道.最近,南开大

Chiral heterocyclic carboxylic acids are important synthesis intermediates for many chiral drugs and are also the core skeleton of many natural products. Asymmetric catalytic hydrogenation of unsaturated heterocyclic carboxylic acids is the most efficient method for the synthesis of chiral heterocyclic carboxylic acids Although many highly efficient chiral catalysts have been developed to achieve high enantioselective hydrogenation of a wide variety of chain-like unsaturated carboxylic acids, the asymmetric catalytic hydrogenation of cyclic unsaturated carboxylic acids has been less successful Example. Recently, Nankai University