吗啡对备用根大鼠脊髓后角组织提取液促进神经突起生长的影响

• 作 者: 曾园山 章尧 郭畹华 罗超权
• 机 构: 中山医科大学组织学胚胎学教研室神经科学研究室,中山医科大学组织学胚胎学教研室神经科学研究室,中山医科大学组织学胚胎学教研室神经科学研究室,中山医科大学组织学胚胎学教研室 广州510089,广州5100
• 出 处: 解剖学报
• 发表日期: 1995年03期
• 关键词: 突起生长 脊髓后角 背根 大鼠 突触重建 促进神经 神经突起 内侧支 初级传入 生长晕

为探讨吗啡促进备用根大鼠背根节神经元发出的初级传入纤维在脊髓内侧支出芽和突触重建的机制,将成年的大鼠分为吗啡备用根组(6只)和备用根对照组(6只)。前组动物在施行备用根模型手术的前、后给予吗啡注射,后组动物除没有使用吗啡外,其余处理与前组相同。切除两组动物脊髓左侧L_1～L_3、L_5、L-6背根和背根节,保留L_4背根(作为备用根)。于手术后第5d分别取出两组动物腰段手术侧和非手术侧脊髓后角组织块,按

In order to investigate the mechanism of morphine on primary budding and synaptic reconstruction of primary afferent fibers from dorsal root ganglion neurons in spinal cord of adult SD rats, adult rats were divided into morphine standby root group (6) and control Group (6). The animals in the former group were given morphine injection before and after the operation of the backup root model. The animals in the latter group except the morphine were not treated with morphine, and the rest were the same as the former group. L_1 ~ L_3, L_5, L-6 dorsal root and dorsal root ganglion were removed from left side of spinal cord in both groups, and L_4 dorsal root was reserved as spare root. At the 5th day after operation, two groups of lumbar lumbar surgery and non-surgical spinal dorsal horn tissue blocks were removed,