论文部分内容阅读
Aim:Recent studies have shown that 1-tetrahydropalmatine(l-THP),an activecomponent of Corydolis yanhusuo,can inhibit the development of the condi-tional place preference induced by opioid receptor agonists,but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not beendocumented.In the present study,the effects of l-THP on locomotor sensitizationto oxycodone,which is an opioid receptor agonist,were studied.Methods:Micetreated daily for 7 d with 5 mg/kg oxycodone and challenged with the same doseafter 5 days of washout showed locomotor sensitization.In order to study theeffects of l-THP on locomotor sensitization induced by oxycodone,l-THP wasadministered at doses of 6.25,12.5,and 18.75 mg/kg,40 min prior to treatment ofoxycodone.Results:l-THP per se did not affect the locomotor activity at thedoses of 6.25,12.5,and 18.75 mg/kg,but could antagonize the hyperactivity in-duced by oxycodone(5mg/kg).Co-administration of l-THP(18.75 mg/kg),40 minprior to oxycodone,could inhibit the development of sensitization to oxycodone.In addition,l-THP(6.25,12.5,and 18.75 mg/kg,ig)dose-dependently preventedthe expression of oxycodone sensitization.Conclusion:These results suggestedthat l-THP could attenuate the locomotor-stimulating effects of oxycodone andinhibit the development and expression of oxycodone behavioral sensitization.
Aim:Recent studies has shown that 1-tetrahydropalmatine(l-THP),an active component of Corydolis yanhusuo,can inhibit the development of the condi-tional place preference induced by opioid receptor agonists,but the effects of l-THP on locomotor sensitivityinduced By opioid receptor agonists have not been documented.In the present study,the effects of l-THP on locomotor sensitizationto oxycodone,which is an opioid receptor agonist,we studied.Methods:Micetreated daily for 7 d with 5 mg/kg oxycodone and challenged with The same dose after 5 days of washout showed locomotor sensitization.In order to study the effects of l-THP on locomotor sensitization induced by oxycodone,1-THP wasadministered at doses of 6.25,12.5, and 18.75 mg/kg,40 min prior to treatment ofoxycodone .Results: l-THP per se did not affect the locomotor activity at the doses of 6.25,12.5, and 18.75 mg/kg,but could antagonize the hyperactivity in-duced by oxycodone(5mg/kg).Co-administration of l-THP (18.75 mg/kg), 40 minprior to o Xycodone, could inhibit the development of sensitization to oxycodone.In addition, l-THP(6.25,12.5,and 18.75 mg/kg,ig)dose-dependently prevented the expression of oxycodone sensitization.Conclusion:The results results suggestedthat l-THP could attenuate the Locomotor-stimulating effects of oxycodone andinhibit the development and expression of oxycodone behavioral sensitization.