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生存素(survivin)是一种结构独特的哺乳类凋亡抑制蛋白家族新成员,其在多种肿瘤中表达,使应用靶向生存素的阻断性基因治疗肿瘤成为可能。本文以生存素为靶基因治疗裸鼠皮下种植瘤,观察其疗效及不良反应,以求进一步探索肿瘤治疗的新途径。材料与方法一、细胞培养HT-29结肠腺癌细
Survivin is a novel member of the mammalian apoptosis-inhibitory protein family that is unique in its structure and is expressed in a variety of tumors, making it possible to treat cancer using blocking genes targeting survivin. In this paper, survivin as the target gene in nude mice subcutaneously implanted tumors observed its efficacy and adverse reactions in order to further explore new ways of cancer treatment. Materials and methods First, the cell culture HT-29 colon adenocarcinoma fine