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文章简介机体每秒钟约有10~6个细胞凋亡,如被及时清除则维持机体稳定,反之则导致自身免疫病、慢性炎症、发育异常等,但凋亡细胞吞噬清除机制目前尚未阐明。既往研究发现凋亡细胞释放“find me”分子趋化吞噬细胞而起始吞噬,本研究则发现凋亡细胞分泌“find me”分子可激活促红细胞生成素通路进而激活PPARγ吞噬通路导致
Article Introduction About 10 ~ 6 cell apoptosis occurs every second. If it is removed in time, it will maintain the stability of the body. Otherwise, it will lead to autoimmune diseases, chronic inflammation and dysplasia. However, the phagocytosis mechanism of apoptotic cells has not been elucidated yet. Previous studies have found that apoptotic cells release chemotaxis to chemotactic phagocytic cells. In this study, we found that apoptotic cells secrete “find me” molecules that activate the erythropoietin pathway and activate the PPARγ phagocytosis pathway resulting in