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研究了一种基于马赫-曾德尔结构的相差表面等离子体共振(SPR)传感器系统。和传统的相位型SPR传感系统相比,该系统采用了p偏振光与s偏振光各自干涉后再相位相减来提取样品折射率信息的方法,从而显著降低了环境噪声的影响,提高了分辨率。系统最小可区分0.01°的相差,对应的分辨率为10-5 RIU(折射率单位)。应用此系统进行了生物大分子结合反应的测量,分辨率可达每平方微米160个IgG分子。研究结果为表面等离子体共振传感器在生物医学的应用提供了一定的参考。
A Phase Difference Surface Plasmon Resonance (SPR) sensor system based on Mach-Zehnder structure is studied. Compared with the traditional phase SPR sensor system, the system extracts the refractive index of the sample by the phase-subtraction between the p-polarized light and the s-polarized light, then significantly reduces the influence of environmental noise and improves Resolution. The system can be distinguished by a minimum of 0.01 ° with a resolution of 10-5 RIU (Refractive Index Units). The system was used to measure the binding of biological macromolecules with a resolution of 160 IgG molecules per square micron. The results provide a reference for the application of surface plasmon resonance sensors in biomedicine.