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十年前,普遍认为复杂性煤矿工人尘肺的团块状病变是一种伴有煤尘灶的胶元纤维组织块(称之为进行性块状纤维化,即PMF)。Nagelshmidt及其同事(1963)对这种观点首先提出异仪。他们认为,如果将病变中的羟脯氨酸量做为胶元量的指征,则PMF病变中的胶元同病变围围肺组织相比并没有明显增加。为了查清团块病变的组成,本文对六例PMF的肺组织进行了生化、超微结构和免疫学特征的综合研究。电镜研究表明,星形结节周围是胶元,靠近结节中心因无定形物质在胶元纤维之间蔓延而造成纤维结构的中断或分割。越靠病变中心,无定形物质越突出。
Ten years ago, it was generally accepted that the massive lesions of the complex coal miners’ pneumoconiosis were colloidal fibrous tissue with a coal dust (referred to as progressive massive fibrosis, or PMF). Nagelshmidt and coworkers (1963) first made a difference in this view. In their opinion, if the amount of hydroxyproline in the lesion is used as an indication of the amount of collogen, the amount of collogen in the PMF lesion does not significantly increase as compared with the lesion-surrounding lung tissue. In order to find out the composition of the clumps, we studied the biochemical, ultrastructural and immunological characteristics of six PMF lung tissues. Electron microscopy studies have shown that around the star nodules are collagen, near the center of the nodules due to the spread of amorphous substances in the fiber between the fibers caused by the interruption or split fiber structure. The more the lesion center, the more prominent amorphous material.