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51例女性患有急性尿路感染曾用新诺塞辛(Cinoxacin)治疗,它是一种新的合成药,其化学性与抗菌性与萘啶酸(Nalidixic acid)相似。治疗前作了尿培养,在7—10天治疗过程中,治疗一周后,如果可能治疗4—6周后也采尿培养。治疗前、中、后要测定肾、肝功能和全血检常规。所有病人都认为患有下尿路的感染。在51例中有48例在治疗中尿培养转为无菌(94％)而且有42例(92％)在治疗后尿培养阴性维持一周。在这些病人中进行尿培养追踪至治疗后4—6周,72％仍为无菌尿。没有明显的血液、肾、肝及胃肠道的毒性表现。新诺塞辛似乎是一种对革兰氏阴性菌引起的泌尿系感染安全而有效的治疗药物,而且在几种测试剂量表中其效能没有多大差别。
Fifty-one women with acute urinary tract infection were treated with Cinoxacin, a new synthetic drug with similar chemical and antibacterial properties to nalidixic acid. Urine culture was performed prior to treatment, and during the 7-10 days of treatment, one week after treatment, urine cultures were also taken if possible after 4-6 weeks of treatment. Before treatment, after the determination of kidney, liver function and blood test routine. All patients are thought to have an infection of the lower urinary tract. In 51 of the 48 patients, urinary cultures turned sterile (94%) during treatment and 42 (92%) had negative urine cultures for one week after treatment. Urine culture was followed up in these patients to 4-6 weeks after treatment, with 72% still being sterile urine. No obvious blood, kidney, liver and gastrointestinal toxicity. Nocissin appears to be a safe and effective treatment for urinary tract infections caused by Gram-negative bacteria and does not differ in potency in several test dosages.