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本文根据硬X射线衍射增强成像(Diffraction enhanced imaging,DEI)原理,对由人血白蛋白诱导的大鼠肝纤维化模型进行了成像研究。实验在北京同步辐射装置(Beijing Synchrotron Radiation Facility,BSRF)4W1A光束线形貌站完成。结果表明:正常及不同程度肝纤维化模型在DEI图像上差异显著,图像感兴趣区的光强分布及纹理测度也显示出这种差异。DEI成像为肝纤维化的诊断提供了一种潜在的影像学途径。
Based on the principle of Diffraction enhanced imaging (DEI), we studied the imaging of hepatic fibrosis induced by human serum albumin. Experiments were performed at Beijing Synchrotron Radiation Facility (BSRF) 4W1A beamline topography station. The results showed that there were significant differences in DEI images between normal and different degrees of liver fibrosis models, and the difference of light intensity distribution and texture measure in the region of interest of images also showed this difference. DEI imaging provides a potential imaging modality for the diagnosis of liver fibrosis.