论文部分内容阅读
目的:探讨近足月胎膜早破时间、血清C反应蛋白与绒毛膜羊膜炎的关系以及预防性应用抗生素的临床效果。方法:对115例近足月胎膜早破患者分成3组,<8 h 35例,8～12 h 41例,>12 h 39例。其中,<8 h 35例又分成服药组18例,未服药组17例;8～12 h 41例又分成服药组21例,未服药组20例;>12 h 39例均服药。产后(包括剖宫产术后)胎盘送病理检查,检测各组绒毛膜羊膜炎发生率和CRP水平。结果:近足月胎膜早破<8 h服药组绒毛膜羊膜炎的发生率为11.0%,未服药组11.7%,两组绒毛膜羊膜炎发生率差异无统计学意义(P>0.05)。8～12 h服药组绒毛膜羊膜炎的发生率为57.1%,未服药组70.0%,未服药组明显高于8～12 h服药组(P<0.05)。>12 h绒毛膜羊膜炎的发生率为84.6%,而且程度较重,与前两者服药组比较差异有统计学意义(P<0.05)。结论:近足月胎膜早破>8 h均应给予抗生素预防感染,监测C反应蛋白,适时终止妊娠,以减少母儿并发症。
Objective: To investigate the relationship between premature rupture of membranes and serum C-reactive protein and chorioamnionitis and the clinical effect of prophylactic antibiotics. Methods: One hundred and fifteen cases of premature rupture of membranes were divided into 3 groups: 35 cases in <8 h, 41 cases in 8-12 h, 39 cases in> 12 h. Among them, <8 h 35 cases were divided into medication group 18 cases, 17 cases without medication group; 8 to 12 h 41 cases were divided into medication group 21 cases, no medication group 20 cases;> 12 h 39 cases were taking medication. Postpartum (including cesarean section) placenta sent to pathological examination, the incidence of chorioamnionitis in each group and CRP levels were measured. Results: The incidence of chorioamnionitis in premature rupture of membranes in 8 h was 11.0% and 11.7% in non-medication group, respectively. There was no significant difference in the incidence of chorioamnion between the two groups (P> 0.05). The incidence of chorioamnionitis was 57.1% in the 8-12 h group, 70.0% in the non-medication group, and significantly higher than that in the 8-12 h group (P <0.05). > 12 h chorioamnionitis incidence was 84.6%, and to a greater extent, compared with the former two medication group was statistically significant (P <0.05). CONCLUSION: Premature rupture of membranes should be given antibiotics to prevent infection, detect C-reactive protein and terminate pregnancy at the right time in order to reduce the complications of maternal and infant.