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目的探讨慢性心力衰竭(CHF)患者血清血管生成素-2(Ang-2)的表达水平及临床意义。方法选择CHF患者113例,对不同心功能分级(NYHA心功能分级:Ⅰ级32例,Ⅱ级30例,Ⅲ级26例,Ⅳ级25例)的CHF患者血清Ang-2、N-末端利钠肽前体(NT-proBNP)和左室射血分数(LVEF)进行检测,并设对照组20例(同期健康体检者)。结果 NYHA心功能Ⅰ级~Ⅳ级的CHF患者,NT-proBNP和Ang-2的表达水平逐渐升高,各组间差异均具有统计学意义(P<0.05)。相关性分析显示,Ang-2与NT-proBNP呈显著的正相关(r=0.774,P<0.001),Ang-2与LVEF呈显著的负相关(r=-0.725,P<0.001)。结论 Ang-2与心力衰竭严重程度有着明显的相关性,提示其对心力衰竭的诊断及评价预后有一定的临床意义。
Objective To investigate the expression of serum Angiopoietin-2 (Ang-2) in patients with chronic heart failure (CHF) and its clinical significance. Methods A total of 113 patients with CHF were enrolled in this study. Serum levels of Ang-2 and N-terminal in CHF patients with different cardiac function classification (NYHA functional class: 32 cases of grade Ⅰ, 30 cases of grade Ⅱ, 26 cases of grade Ⅲ and 25 cases of grade Ⅳ) (NT-proBNP) and left ventricular ejection fraction (LVEF) were detected in 20 cases (control group). Results The expression of NT-proBNP and Ang-2 in CHF patients with NYHA functional class Ⅰ ~ Ⅳ gradually increased. The differences among the groups were statistically significant (P0.05). Correlation analysis showed that there was a significant positive correlation between Ang-2 and NT-proBNP (r = 0.774, P <0.001), and negative correlation between Ang-2 and LVEF (r = -0.725, P <0.001). Conclusions There is a significant correlation between Ang-2 and the severity of heart failure, suggesting that it has certain clinical significance for the diagnosis and prognosis of heart failure.