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从临床肝病患者中选择两例ＨＣＶ和ＨＢＶ重叠感染者ＨＳＱ和ＳＺＨ，他们血清中的生化指标丙氨酸转氨酶（ＡＬＴ）持续异常，肝活检病理示有严重的肝损伤。在ＡＬＴ异常期，血清学检测结果为ＨＢｓＡｇ、ＨＢｅＡｇ阳性，抗ＨＣＶＩｇＧ（包括Ｃ２２、Ｃ３３ｃ）阴性，但套式ＰＣＲ检测ＨＣＶＲＮＡ阳性，核心区ｃＤＮＡ序列分析发现该区有１个密码子（ＧＧＣｎｔ３８５—３８７）缺失，对应缺失的氨基酸是甘氨酸（ＧＬＹ），从血清学检测和序列分析结果推测，在ＨＣＶ和ＨＢＶ重叠感染中，ＨＢＶ和ＨＣＶ均可处于持续复制状态，抗ＨＣＶＩｇＧ抗体阴性可能是ＨＣＶ的多蛋白前体翻译和病毒颗粒装配受到ＨＢＶ干扰的结果。
Two patients with HCV and HBV coinfected HSQ and SZH were selected from clinical liver disease patients. Their serum biochemical indicators alanine aminotransferase (ALT) continued to be abnormal, and liver biopsy showed severe liver injury. In abnormal ALT, the results of serological tests were HBsAg, HBeAg positive and anti-HCVIgG (including C22, C33c) negative, but the nested PCR showed that HCVRNA was positive. CDNA analysis of core region showed that there was 1 codon (GGCnt385-387 ) Is missing, and the corresponding missing amino acid is glycine (GLY). Based on the results of serological test and sequence analysis, HBV and HCV can be replicated continuously in HCV and HBV, and the anti-HCVIgG antibody may be HCV negative Protein precursor translation and viral particle assembly as a result of HBV interference.