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精子在正常情况下被血睾屏障所分隔,破坏这一屏障能导致精子凝集抗体或制动抗体的生成。这种情况至少在接种精子自体固有抗原的实验动物中可以发生。如果把精子和弗氏佐剂一同接种,其结果将引起一种细胞介导的免疫反应,伴发免疫性睾丸炎和变态反应性无精症,但是,对于这种实验性抗精子抗体的产生和人类不育的关系,有人表示怀疑。关于这一问题的许多混乱,若能说明下列两点就能解除疑问:首先,发表文章时应在男性和女性中所获结果之间明确地加以区别(女性可能反映不同的现象,且定然会有不同的临床含意);其次,与影响生育
Sperm is normally separated by the blood-testis barrier, and disrupting this barrier can lead to the formation of sperm-agglutinating antibodies or brake antibodies. This condition can occur in at least the experimental animals vaccinated with sperm autologous antigen. If the sperm is inoculated with Freund’s adjuvant, the result will be a cell-mediated immune response accompanied by immunogenic orchitis and allergic azoospermia. However, the production of such experimental anti-sperm antibodies And human infertility, some people expressed doubts. Much of the confusion on this issue can be resolved by describing the point that, first, the article should be clearly differentiated between the results obtained by men and women (women may reflect different phenomena and will certainly Have different clinical implications); second, and affect fertility