Interaction of IFNL3 with insulin resistance,steatosis and lipid metabolism in chronic hepatitis C v

• 作 者: Mohammed Eslam David R Booth Jacob George Golo Ahlenstiel
• 机 构: Storr Liver Unit,Westmead Millennium Institute and Westmead Hospital,University of Sydney,Sydney,NSW
• 出 处: World Journal of Gastroenterology
• 发表日期: 2013年41期
• 关键词: metabolism lipid picture genotype pathogenesis clearance interferon regarding ob

Metabolic changes are inextricably linked to chronic hepatitis C(CHC).Recently polymorphisms in the IFNL3(IL28B)region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus(HCV)infection.Further,circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism,steatosis and insulin resistance in CHC.The emerging picture suggests that the responder genotypes of IFNL3polymorphisms are associated with a higher serum lipid profile,and less frequent steatosis and insulin resistance.This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression.

Metabolic changes are inextricably linked to chronic hepatitis C (CHC). Repeated polymorphisms in the IFNL3 (IL28B) region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus (HCV) infection. Future, circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism, steatosis and insulin resistance in CHC. The emerging picture suggests that the responder genotypes of IFNL3 polymorphisms are associated with a higher serum lipid profile, and less frequent steatosis and insulin resistance. this review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression.