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目的探讨胃癌组织中肿瘤坏死因子受体Ⅰ、Ⅱ(TNFRⅠ、Ⅱ)表达量与临床病理因素及肿瘤分期间的关系。方法用免疫组织化学SABC法检测51例胃癌组织、41例癌旁组织及15例正常胃粘膜中TNFRⅠ、Ⅱ的表达。结果胃癌组织中TNFRⅠ、Ⅱ表达均比癌旁组织及正常组织显著增高(P<0.05),且癌旁组织TNFRⅠ、Ⅱ表达亦显著高于正常组织(P<0.05)。在胃癌组织中,TNFRⅠ、Ⅱ表达与和浆膜浸润和淋巴结转移无关,而与肿瘤分化程度有关(r=-0.3111,P=0.035;r=-0.5952,P=0.000),当肿瘤分化程度低时TNFRⅠ、Ⅱ表达低。结论TNFRⅠ、Ⅱ检测对判断胃癌恶性程度有重要价值。
Objective To investigate the relationship between tumor necrosis factor receptor Ⅰ, Ⅱ (TNFR Ⅰ, Ⅱ) expression and clinicopathological factors and tumor stage in gastric cancer. Methods Immunohistochemical SABC method was used to detect the expression of TNFRⅠ and Ⅱ in 51 cases of gastric cancer, 41 cases of paracancerous tissues and 15 cases of normal gastric mucosa. Results The expressions of TNFR Ⅰ and Ⅱ in gastric cancer tissues were significantly higher than those in paracancer tissues and normal tissues (P <0.05). The expressions of TNFR Ⅰ and Ⅱ in adjacent tissues were also significantly higher than those in normal tissues (P <0.05). In gastric cancer, the expression of TNFRⅠ and Ⅱ was not related to serosal invasion and lymph node metastasis, but correlated with tumor differentiation (r = -0.3111, P = 0.035; r = -0.5952, P = 0.000) When TNFR Ⅰ, Ⅱ expression is low. Conclusion The detection of TNFR Ⅰ and Ⅱ is of great value in judging the malignant degree of gastric cancer.