Gene editing in T cell therapy

• 作 者: Yongping Zhang Wei Mu Haoyi Wang
• 机 构: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of
• 出 处: Journal of Genetics and Genomics
• 发表日期: 2017年09期
• 关键词: Gene editing CRISPR-Cas9 T cells

The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise. Gene editing holds tremendous potential for further improvements of T cell therapy. Here we review the applications of gene editing in various T cell therapies, focusing on antiviral strategies and cancer immunotherapies, and discuss the challenges and future prospects.

The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise. Gene editing holds tremendous potential for further improvements of T cell therapy. Here we review the applications of gene editing in various T cell therapies, focusing on antiviral strategies and cancer immunotherapies, and discuss the challenges and future prospects.