论文部分内容阅读
Lactate dehydrogenase(LDH),as an indicator of cell damageor death,was used to determine the diphosgene damage of respiratorytract cells.Guinea-pigs were exposed to diphosgene at concentrationswithin the LCt_(50) range and above.The content of LDH in thebronchopulmonary washings of guinea-pigs was significantly increa-sed after poisoning.There was no increase of free hemoglobincontent in the washings.It was indicated that lysed erythrocyteswere not the source of LDH in the poisoned group.The LDH iso-enzyme pattern in the poisoned group washings suggests that theincreased LDH comes from the respiratory tract cells.These resultsshow diphosgene can directly damage cells of the respiratory tract.
Lactate dehydrogenase (LDH), as an indicator of cell damageor death, was used to determine the diphosgene damage of respiratory tract cells. Guinea-pigs were exposed to diphosgene at concentrations with in the LCt_ (50) range and above. The content of LDH in the bronchopulmonary washings of guinea-pigs was significantly increa-sed after poisoning. There was no increase of free hemoglobincontent in the washings. It was indicated that lysed erythrocytes were not the source of LDH in the poisoned group. LDH iso-enzyme pattern in the poisoned group washings suggests that theincreased LDH comes from the respiratory tract cells.These resultsshow diphosgene can directly damage the of the respiratory tract.