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The islet transcription factor pancreatic duodenalhomeobox-1 (PDX-1, also known as insulin promoterfactor-1 or IPF-1) is an orphan homeodomain protein thatplays an important role in the development, proliferation,differentiation and maturation of pancreatic cells. It isinitially detected in the part of the dorsal and ventralprimitive gut epithelium that later develops into thepancreas in embryonic period. In adults, its expression isfound predominantly in the differentiated islet beta-cells.A recent study shows that PDX-1 is a major islettranscription factor which activates insulin genetranscription. Glucose-induced insulin biosynthesis isconcerned with some motifs in insulin gene promoter, andPDX-1 activates insulin gene transcription and
The islet transcription factor pancreatic duodenal homeobox-1 (PDX-1, also known as insulin promoter factor-1 or IPF-1) is an orphan homeodomain protein thatplays an important role in the development, proliferation, differentiation and maturation of pancreatic cells. It is inially titrated in the part of the dorsal and ventralprimitive gut epithelium that later develops into the pancreas in embryonic period. In adults, its expression is found predominantly in the differentiated islet beta-cells. A recent study shows that PDX-1 is a major islet transcription factor which activates insulin genetranscription. Glucose-induced insulin biosynthesis isconcerned with some motifs in insulin gene promoter, and PDX-1 activates insulin gene transcription and