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目的研制口腔用塞克硝唑棒剂并评价其临床疗效。方法研究塞克硝唑棒剂的制备工艺,对该制剂进行质量控制。以甲硝唑棒为对照,考察治疗牙周炎的疗效。结果塞克硝唑棒剂质量控制方法能够控制其产品质量;治疗牙周炎有效率达98.53%,与甲硝唑棒比较疗效差异显著。结论塞克硝唑棒剂质量可控,治疗牙周炎疗效好,值得推广应用。
OBJECTIVE To develop oral use of Secnidazole and evaluate its clinical efficacy. Methods To study the preparation process of sedentanazole sticks and to control the quality of the preparation. Metronidazole rods as a control, study the efficacy of treatment of periodontitis. Results The quality control method of Secnidazole sticks could control the quality of its products. The effective rate of treating periodontitis was 98.53%, which was significantly different from metronidazole sticks. Conclusions The quality of sedentan rod is controlled, the effect of treating periodontitis is good, and it is worth popularizing and applying.