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目的治疗组观察盐酸丁咯地尔注射液联合怡开治疗2型糖尿病周围神经病变的疗效。方法 62例2型糖尿病并发周围神经病变患者随机分为治疗组32例,对照组30例。两组均予以盐酸丁咯地尔200mg溶于250ml生理盐水中静脉滴注,每日1次,治疗组联合怡开40U肌注,每日1次。结果治疗4周后,两组神经症状均得到改善,且治疗组TSS评分改善与对照组比较,差异有统计学意义(P<0.05);治疗组四肢震动感觉阈值改善较对照组明显(P<0.05)。结论盐酸丁咯地尔注射液联合怡开治疗2型糖尿病周围神经病变有较好的疗效。
Objective To observe the curative effect of Buflomedil Hydrochloride Injection and Yiqi on Type 2 Diabetic Peripheral Neuropathy. Methods Sixty-two patients with type 2 diabetes complicated with peripheral neuropathy were randomly divided into treatment group (n = 32) and control group (n = 30). Both groups were given Buflomedil 200mg dissolved in 250ml normal saline intravenously 1 day, the treatment group combined with Yue 40U intramuscularly, once daily. Results After 4 weeks of treatment, the neurological symptoms were improved in both groups, and TSS score improved in the treatment group compared with the control group, the difference was statistically significant (P <0.05); the sensory threshold of the limbs in the treatment group was significantly improved compared with the control group (P < 0.05). Conclusions Buflomedil hydrochloride injection combined with Yiqi treatment of type 2 diabetic peripheral neuropathy has a good effect.