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【目的】检测产妇以及脐带血中维生素A,E,C以及β-胡萝卜素的含量并分析其与新生儿出生结果的关系。【方法】分娩后立即收集1 6 6对产妇和脐带血并利用HPLC法分别没定各种抗氧化维生素浓度,同时测定新生儿的身长、体重和头围。【结果】多元逐步回归分析显示产妇维生素A水平每升高1μmol/L,出生体重下降2 4.2 g(9 5%CI:-4 1.5~-5.9,P<0.01);维生素A胎盘转运率每增加1%,出生身长增加0.8 cm(9 5%CI:0.004~1.639,P=0.049)。产妇β-胡萝卜素水平每升高1μmol/L,出生体重增加12.4 g(9 5%CI:7.1~25.3,P=0.024)、出生身长增加约0.6 cm(9 5%CI:0.01~1.2 1,P=0.032)。【结论】孕期维生素A、β-胡萝卜素水平与新生儿发育水平具有相关性。
【Objective】 To detect the content of vitamin A, E, C and β-carotene in maternal and umbilical cord blood and to analyze their relationship with the newborn’s birth result. 【Method】 Immediately after delivery, 166 maternal and umbilical cord blood samples were collected and various concentrations of antioxidant vitamins were determined by HPLC. The body length, body weight and head circumference of newborns were also determined. 【Result】 Multivariate stepwise regression analysis showed that for every increase of vitamin A level by 1 μmol / L and birth weight loss by 4.2 g (95% CI: -4 1.5 -5.9, P <0.01) 1% increase in birth length 0.8 cm (95% CI: 0.004 ~ 1.639, P = 0.049). The increase of β-carotene level at birth by 1 μmol / L, birth weight gain by 12.4 g (95% CI: 7.1-25.3, P = 0.024) and birth length by 0.6 cm (95% CI: 0.01-1.21, P = 0.032). 【Conclusion】 The levels of vitamin A and β-carotene during pregnancy are correlated with the development of neonates.