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目的 探讨子宫内膜异位症 (内异症 )患者血清中可溶性血管细胞粘附因子 1(sVCAM 1)水平的变化及意义。方法 采用酶联免疫吸附法 (ELISA)检测 15例内异症及 15例对照组患者血清sVCAM 1水平。结果 ①内异症组与对照组血清sVCAM 1水平相比差异有显著意义 (P <0 0 1)。②内异症Ⅰ～Ⅱ期患者与Ⅲ～Ⅳ期患者血清sVCAM 1水平之间差异有显著意义 ,而内异症组与对照组相比患者增殖期及分泌期血清sVCAM 1差异无显著意义。结论 可溶性血管细胞粘附因子 1(sVCAM 1)在子宫内膜异位症的发病中有一定作用。
Objective To investigate the changes and significance of serum soluble vascular cell adhesion factor 1 (sVCAM 1) in patients with endometriosis (endometriosis). Methods Serum levels of sVCAM 1 in 15 patients with endometriosis and 15 controls were detected by enzyme-linked immunosorbent assay (ELISA). Results ① There was significant difference in serum sVCAM 1 level between endometriosis group and control group (P <0.01). ② The difference of serum sVCAM 1 levels between stage Ⅰ ~ Ⅱ endometriosis patients and stage Ⅲ ~ Ⅳ stage patients was significant, while there was no significant difference between the endometriosis group and the control group in the stage of proliferative and secretory stage serum sVCAM 1. Conclusion The soluble vascular cell adhesion factor 1 (sVCAM 1) may play a role in the pathogenesis of endometriosis.