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目的:了解不同构型甘草酸制剂对慢型乙型肝炎的治疗作用。方法:β-甘草酸和α- 甘草酸各60 mL分别加入葡萄液中静脉滴注,一个月后观察肝功能改善情况。结果:β-甘草酸组治疗后谷丙转氨酶(ALT)较治疗前明显下降(P<0．01),对照的α-甘草酸组治疗后ALT较治疗前也明显下降(P<0．05);两组治疗前后有效率比较,差异有统计学意义(P<0．05)。结论:β- 甘草酸和α-甘草酸均能有效改善肝功能,但β-甘草酸优于α-甘草酸。
Objective: To understand the therapeutic effect of different configurations of glycyrrhizin on chronic hepatitis B. Methods: Sixty mL each of β-glycyrrhizic acid and α-glycyrrhizic acid were added to the grape vein for intravenous drip. After one month, the improvement of liver function was observed. Results: The alanine aminotransferase (ALT) in β-glycyrrhizin group was significantly lower than that before treatment (P <0.01), and the ALT in α-glycyrrhizinate group was significantly lower than that before treatment (P <0.05 ); The two groups before and after treatment, the difference was statistically significant (P <0.05). Conclusion: Both β-glycyrrhizin and α-glycyrrhizinate can effectively improve liver function, but β-glycyrrhizin is superior to α-glycyrrhizinate.