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目的分析百草枯中毒患者急性肾损伤(AKI)的病因,探讨影响其预后的危险因素,为早发现、早治疗和改善预后提供帮助。方法将资料完整的181例患者分为有急性肾损伤组和无急性肾损伤组,采用单因素分析初步筛查出AKI的危险因素,然后将初筛有统计学意义的因素进行Logistic回归分析,判断各因素对AKI的影响。结果 181例急性百草枯中毒患者中50例出现AKI,死亡46例,无急性肾损伤者131例,死亡46例,2组死亡率差异有统计学意义(P<0.001)。Logistic回归分析表明血中性粒细胞计数、血糖、血尿素氮及消化道出血等与百草枯患者发生AKI有较强的相关性(OR值为1.117、1.134、1.477和9.366)。结论血中性粒细胞计数及血糖升高、发生消化道出血为百草枯中毒患者发生AKI的危险因素。
Objective To analyze the etiopathogenisis of acute kidney injury (AKI) in patients with paraquat poisoning and to explore the risk factors influencing its prognosis, so as to help early detection, early treatment and prognosis. Methods A total of 181 patients with complete data were divided into acute renal injury group and no acute renal injury group. The risk factors of AKI were screened by univariate analysis. Logistic regression analysis was used to analyze the statistically significant factors of primary screening, To determine the impact of various factors on AKI. Results AKI was found in 50 out of 181 patients with acute paraquat poisoning, with 46 deaths, 131 without acute kidney injury and 46 deaths. There was significant difference in mortality between the two groups (P <0.001). Logistic regression analysis showed that blood neutrophil count, blood glucose, blood urea nitrogen and gastrointestinal bleeding with paraquat in patients with AKI have a strong correlation (OR values of 1.117,1.134,1.477 and 9.366). Conclusion The blood neutrophil count and blood sugar increased, and the occurrence of gastrointestinal bleeding is a risk factor for paraquat poisoning in patients with AKI.