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盐酸万乃洛韦是L—缬氨酸阿昔洛韦酯,本品是阿昔洛韦的前体,水溶性好,进入体内迅速吸收,并水解出母体阿昔洛韦而抑制病毒DNA的合成从而抑制其复制。对单纯疱疹病毒和带状疱疹病毒的抑制作用强,对水痘疱疹病毒、EB病毒以及巨细胞病毒的抑制作用弱。用于治疗水痘带状疱疹及Ⅰ型、Ⅱ型单纯疱疹,包括初发和复发的生殖器疱疹,对于阿昔洛韦治疗无效或不敏感的严重疱疹病毒感染和乙型肝炎也仍然有效。 1 药物动力学 口服、静脉给药均有效。在空腹的情况下吸收迅速,5min血药浓度达峰值,是阿昔洛韦口服生
Valacyclovir hydrochloride is L-valine acyclovir ester, this product is a precursor of acyclovir, water-soluble, quickly absorbed into the body, and hydrolysis of the mother acyclovir and inhibit viral DNA Synthesis to inhibit its replication. Strong herpes simplex virus and herpes zoster virus inhibition, the chicken pox herpes virus, Epstein-Barr virus and cytomegalovirus inhibition is weak. It is also effective in the treatment of varicella zoster and herpes simplex types I and II, including both primary and recurrent genital herpes, severe herpes virus infections and hepatitis B that are ineffective or insensitive to acyclovir treatment. Pharmacokinetic oral and intravenous administration are effective. Rapid absorption in the fasting case, 5min peak plasma concentration, acyclovir oral health