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目的探讨通冠化浊汤加减对大鼠高脂血症模型血液流变学的影响性,以期寻找更加有力的证据,提高临床诊治水平。方法采用高脂饲料喂养大鼠11周建立高脂血症模型,以血脂水平进行检测是否成功,模型成功后连续灌胃给药不同剂量通冠化浊汤(分别为4,8,12g/kg)和辛伐他丁片(4mg/kg),末次给药后大鼠下腔静脉取血,检测血液流变学。结果血液黏度上,与正常对照组比较,模型对照组大鼠在全血黏度、血浆黏度升高,与模型对照组比较,通冠化浊汤低、中、高剂量在全血黏度、血浆黏度明显下降(P<0.05);在红细胞聚集性上,模型对照组大鼠在红细胞聚集指数、卡松屈服应力、红细胞聚集系数升高,与模型对照组比较,通冠化浊汤低、中、高剂量在卡松屈服应力明显下降(P<0.05);在红细胞变形性上,与正常对照组比较,模型对照组大鼠在红细胞压积、、红细胞变性指数卡松黏度模型升高,与模型对照组比较,通冠化浊汤中、高剂量在红细胞压积、卡松黏度下降,红细胞变形指数升高(P<0.05)。结论通冠化浊汤加减能降低大鼠高脂血症血液粘稠度。
Objective To investigate the effect of Tongguan Huazhotang addition and subtraction on the hemorrheology of hyperlipidemic rats in order to find more powerful evidence and improve the clinical diagnosis and treatment. Methods The rats were fed with high-fat diet for 11 weeks to establish the model of hyperlipidemia. The blood lipid level was used to test the success. After the model was successfully administered, Tongguan Huazhuo Decoction (4,8,12 g / kg ) And simvastatin tablets (4mg / kg). After the last administration, blood was collected from the inferior vena cava of the rats and blood rheology was measured. Results Compared with the normal control group, the blood viscosity of the model control group increased in the whole blood and the plasma viscosity. Compared with the model control group, Tongguan Huazhuo Decoction low, medium and high dose in whole blood viscosity, plasma viscosity (P <0.05). In erythrocyte aggregation, the rats in the model control group had higher erythrocyte aggregation index, Casson’s yield stress, and erythrocyte aggregation coefficient. Compared with the model control group, Tongguan Huazhuo Decoction had lower, Compared with the normal control group, the model control group rats in the hematocrit, the erythrocyte degeneration index cardon viscosity model increased, and the high dose in Cardone yield stress decreased significantly (P <0.05); erythrocyte deformability, Compared with the control group, Tongguan Huazhuo Decoction had higher and higher dosages of erythrocyte hematocrit, lower viscosity of cardon, and higher erythrocyte deformability index (P <0.05). Conclusion Tongguan Huazhuo Decoction can reduce hyperlipemia blood viscosity in rats.