Development and validation for estimation of eplerenone of RP-HPLC method in spiked human plasma

• 作 者: Paraag Gide Sandeep Sonawane A
• 机 构: MET',sInstituteofPharmacy,DepartmentofClinicalSciencesandAdministration
• 出 处: 药物分析学报：英文版
• 发表日期: 2012年5期
• 关键词: RP-HPLC法 人血浆 验证 开发 加权最小二乘法 估计 酮 液体色谱 EplerenoneLiquid-liquidextractionWeighted r
• 基金项目: Authors are thankful to the trustees of Bhujbal Knowledge City, Nashik, for providing analytical facilities and to the Hetero Drug Laboratories, Hyderabad, for providing gift samples of eplerenone and

A rapid and simple high performance liquid chromatography(HPLC) method with a UV detection(241 nm) was developed and validated for estimation of eplerenone from spiked human plasma.The analyte and the internal standard(valdecoxib) were extracted with a mi