Synthesis, Structure and Antimicrobial Activity of 2-Phenyl-4H-spiro[benzo[e][1,4,2]oxaza- phosphini

• 作 者: 刘仁蝶 孔杜林 吴明书 李高楠 李国柱
• 机 构: Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education, College of Chemis
• 出 处: 结构化学
• 发表日期: 2014年02期
• 关键词: spiro Micrococcus diffractometry albus preliminary belongs benzo indolin one 2-o

A novel spiro-compound(C20 H15 N2 O3 P) has been synthesized and characterized by means of IR and 1H NMR. Its crystal structure was determined by X-ray diffractometry. The crystal belongs to the monoclinic system, space group P21 /c with a = 9.1628(7), b = 12.9490(7), c = 15.7898(11), β = 103.952(8)o, Mr = 36.08, V = 1818.2(2)3, Z = 4, Dc = 1.382 g/cm3, F(000) = 788, μ = 0.179 mm-1, R = 0.0701 and wR = 0.1513. The preliminary biological test showed that the title compound has activities against Escherichia coli, S.albus, Bacillus subtilis, Staphylocc- ocusaureus and Micrococcus tetragenus with MIC to be 0.038, 0.038, 0.075, 2.48, and 0.15 mg/mL, respectively.

A novel spiro-compound (C20 H15 N2 O3 P) has been synthesized and characterized by means of IR and 1H NMR. Its crystal structure was determined by X-ray diffractometry. The crystal belongs to the monoclinic system, space group P21 / c with A = 9.1628 (7), b = 12.9490 (7), c = 15.7898 (11) , β = 103.952 (8) o, Mr = 36.08, V = 1818.2 (2) 3, Z = 4, Dc = 1.382 The preliminary biological test showed that the title compound has activities against Escherichia coli, S. albus, Bacillus subtilis, Staphylocc-1, ocusaureus and Micrococcus tetragenus with MIC to be 0.038, 0.038, 0.075, 2.48, and 0.15 mg / mL, respectively.