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目的:通过对凝血酶原时间(PT),活化部分凝血活酶时间(APTT),血浆纤维蛋白原(FIB)凝血酶时间(TT)四项及血小板数量(PLT)的检测,探讨肾病综合征患者这些指标的变化及其临床意义。方法:选取2013年1月到2015年3月就诊于我院并确定为肾病综合征的83例患者为论文研究组;选取同期到我院进行健康体检的正常人65例作为对照组,并对各项结果与对照组进行比较分析。结果:肾病综合征组与正常对照组比较PT、APTT明显缩短(P<0.01),有显著统计学意义;TT缩短(P>0.05),无统计学意义;FIB、PLT明显升高(P<0.01),有显著统计学意义。结论:肾病综合征(NS)患者在临床中常常伴有高凝状态,因此及早检测凝血与血小板参数可以有效的监测本病,预防肾病综合征患者血栓形成。
OBJECTIVE: To investigate the relationship between nephrotic syndrome (PT), thromboplastin time (APTT), fibrinogen (FIB) thrombin time (TT) and platelet count (PLT) Changes in patients with these indicators and its clinical significance. Methods: From January 2013 to March 2015, 83 patients admitted to our hospital and identified as nephrotic syndrome were selected as the research group. 65 normal subjects who were in our hospital for physical examination at the same period were selected as the control group. The results were compared with the control group. Results: Compared with the normal control group, the levels of PT and APTT in nephrotic syndrome group were significantly shorter (P <0.01), and the difference was statistically significant (P <0.05), but there was no statistical significance (P> 0.01), with significant statistical significance. Conclusion: Patients with nephrotic syndrome (NS) often have hypercoagulable state in clinical practice. Therefore, early detection of coagulation and platelet parameters can effectively monitor the disease and prevent thrombosis in patients with nephrotic syndrome.