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目的:通过比较不同严重程度的慢性阻塞性肺疾病(COPD)患者和正常对照者之间的营养指标和静息能量消耗(REE)的变化,初步探讨它们在病程中的变化规律,为临床的营养干预治疗提供理论依据。方法:选择124例稳定期COPD患者(病例组)和45例健康对照者(对照组),分别检测其肺功能、REE、体重指数(BMI)、血清蛋白,并对其结果进行比较分析。结果:(1)REE在病例组和对照组间差别明显,并随阻塞程度加重而升高;(2)BMI随病情加重逐渐降低,在重度COPD组呈低体重状态;(3)血清蛋白随病情变化趋势不明显,但重度COPD组白蛋白仍明显低于其它各组。结论:COPD患者只有在到达重度阻塞程度时,才会表现出明显的营养不良;在COPD的早期阶段,也具有明显营养不良风险,因此对于轻、中度的COPD患者也应给予积极的预防营养不良措施。
OBJECTIVE: To compare the changes of nutritional status and resting energy expenditure (REE) between patients with chronic obstructive pulmonary disease (COPD) and normal controls of different severity, Nutritional intervention provides a theoretical basis for treatment. Methods: 124 patients with stable COPD (case group) and 45 healthy controls (control group) were selected and their lung function, REE, body mass index (BMI) and serum albumin were measured and compared. Results: (1) The difference of REE between case group and control group was obvious, and increased with the increase of obstruction. (2) BMI gradually decreased with the increase of disease, and showed low body weight in severe COPD group. (3) The trend of disease was not obvious, but severe albumin in COPD group was still lower than the other groups. CONCLUSIONS: COPD patients develop significant malnutrition only when severe obstruction is reached, and at an early stage of COPD there is a clear risk of malnutrition, and therefore should be given active preventive nutrition in patients with mild to moderate COPD Bad measure