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目的研究60例颈动脉狭窄患者hs-CRP、Hcy含量变化。方法将2009年9月至2010年12月收入我院的60例颈动脉狭窄患者设为实验组,对照组62例均来自门诊健康体检者。采用荧光偏振免疫法和放射免疫比浊法分别测定Hcy、hs-CRP的浓度,采用颈动脉彩超、MRA或CTA检查颈动脉内膜厚度、有无斑块及狭窄。两组患者的年龄、性别等经统计学分析,差异无统计学意义(P>0.05),具有可比性。结果经测定实验组血浆Hcy的平均浓度为(20.4±7.6)μmol/L,对照组血浆Hcy的平均浓度为(10.4±1.2)μmol/L,经统计学分析,(P<0.01),差异具有统计学意义,即实验组血浆Hcy的水平高于对照组;实验组血清hs-CRP为(8.03±1.93)mg/L,对照组血清hs-CRP为(1.06±0.9)mg/L,经统计学分析,(P<0.01),差异具有显著性,即实验组血清hs-CRP的水平高于对照组。结论 hs-CRP、Hcy含量与颈动脉狭窄程度呈显著正相关,hs-CRP、Hcy可能成为脑血管疾病治疗的新靶点。
Objective To study the changes of hs-CRP and Hcy in 60 patients with carotid artery stenosis. Methods Sixty patients with carotid stenosis who were admitted to our hospital from September 2009 to December 2010 were selected as the experimental group and the control group, 62 patients were from the outpatient health examination. The concentrations of Hcy and hs-CRP were measured by fluorescence polarization immunoassay and radioimmunoassay. The carotid intima-media thickness, plaque and stenosis were examined by carotid ultrasonography, MRA or CTA. Two groups of patients age, gender and other statistical analysis, the difference was not statistically significant (P> 0.05), comparable. Results The mean concentration of Hcy in the experimental group was (20.4 ± 7.6) μmol / L and that in the control group was (10.4 ± 1.2) μmol / L, the difference was statistically significant (P <0.01) The level of plasma Hcy in the experimental group was higher than that in the control group. The serum hs-CRP level in the experimental group was (8.03 ± 1.93) mg / L and the serum hs-CRP level was (1.06 ± 0.9) mg / L in the control group (P <0.01), the difference was significant, that is, the level of serum hs-CRP in the experimental group was higher than that in the control group. Conclusions The levels of hs-CRP and Hcy are positively correlated with the degree of carotid stenosis. Hs-CRP and Hcy may be new targets for the treatment of cerebrovascular diseases.