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目的:观察大豆总黄酮对大鼠骨质疏松的治疗作用。方法:采用12月龄雌性大鼠,切除卵巢60 d以后,以大豆总黄酮250,125,62.5 mg.kg-13个剂量连续灌胃(ig)90 d。测血清碱性磷酸酶(ALP)、钙离子(Ca2+)、磷离子(P3-)、钠离子(Na+)、雌二醇(E2)含量;原子吸收法测定骨Ca2+,P3-,Na+,Mg2+含量;骨扫描法测定胫骨骨密度。结果:以大豆总黄酮250,125 mg.kg-1可以增加骨质疏松大鼠血Ca+2,E2,对血中P3-,Na+离子,ALP含量无明显影响;提高骨Ca2+含量,对骨P3-含量具有一定的升高趋势,对骨Na+,Mg2+无明显影响;增加骨密度和骨小梁面积;减少骨吸收,促进骨形成。结论:大豆总黄酮具有治疗肾虚大鼠骨质疏松作用。
Objective: To observe the therapeutic effect of soybean flavonoids on osteoporosis in rats. Methods: Female 12-month-old female rats were ovariectomized for 60 days. The total flavonoids were treated with 250,125,62.5 mg.kg-13 of soybean for 90 days. The contents of alkaline phosphatase (ALP), calcium (Ca2 +), phosphorus (P3-), sodium (Na +) and estradiol (E2) Content; bone scan determination of tibial bone mineral density. Results: Total dietary flavonoids 250, 125 mg.kg-1 could increase the levels of blood Ca 2+ and E2 in osteoporosis rats, and had no significant effect on the content of P3-, Na + and ALP in blood. The content of Ca2 + Content has a certain upward trend, no significant effect on Na +, Mg2 +; increase bone density and trabecular area; reduce bone resorption and promote bone formation. Conclusion: Soybean total flavonoids can treat osteoporosis in rats with kidney deficiency.