论文部分内容阅读
目的通过热疗加放射治疗的热参数与肿瘤反应的相关性研究，寻找１个更有效的评价热疗疗效的热参数或热剂量。方法对５４例晚期恶性肿瘤进行放射治疗加超声热疗。热疗每周加热２次，每次６０分钟，在放射治疗后３０分钟内进行，共６～１０次，每次都行肿瘤内测温，测温点平均５个，每１０秒记录１个温度数据。最终进行肿瘤反应与肿瘤内最高温度（Ｔｍａｘ），最低温度（Ｔｍｉｎ），平均温度（Ｔａｖ），Ｔ９０，Ｔ５０，Ｔ１０，％Ｔ以及肿瘤中央区测温点温度大于４２℃，４２．５℃的持续时间（ＣｕｍｍｉｎＴｃｅｎｔｅｒ＞４２℃，４２．５℃）等热参数的多元回归分析。结果在可评价的４５例中，总有效率为８０．０％。多元回归分析显示ＣｕｍｍｉｎＴｃｅｎｔｅｒ＞４２．５℃与肿瘤反应差异有显著意义（Ｐ＜０．０１），ＣｕｍｍｉｎＴｃｅｎｔｅｒ＞４２℃，４１℃和Ｔ９０等的反应差异无显著意义。结论放射治疗加超声热疗可进一步提高巨块肿瘤的局部控制率。ＣｕｍｍｉｎＴｃｅｎｔｅｒ＞４２．５℃是一个评价热疗疗效的重要热参数。
Objective To investigate the correlation between thermal parameters of hyperthermia plus radiation therapy and tumor response, and to find a more effective thermal parameter or thermal dose for evaluating the efficacy of hyperthermia. Methods Radiotherapy and ultrasound hyperthermia were performed on 54 cases of advanced malignant tumors. Hyperthermia is heated twice a week for 60 minutes each time, within 30 minutes after radiation therapy, for a total of 6 to 10 times. Each time the temperature within the tumor is measured, the average temperature point is 5, and 1 is recorded every 10 seconds. Temperature data. The final tumor response and tumor maximum temperature (Tmax), the lowest temperature (Tmin), the average temperature (Tav), T90, T50, T10, and %T, and the central tumor temperature measurement point temperature greater than 42 °C, 42.5 °C Multivariate regression analysis of thermal parameters such as duration (CumminTcenter> 42°C, 42.5°C). Results In the 45 cases that could be evaluated, the total effective rate was 80.0%. Multiple regression analysis showed that CumminTcenter>42.5°C had significant difference with tumor response (P<0.01), and CumminTcenter>42°C, 41°C and T90 showed no significant difference. Conclusion Radiotherapy plus ultrasound hyperthermia can further improve the local control rate of giant tumors. Cummin Tcenter>42.5°C is an important thermal parameter to evaluate the therapeutic effect of hyperthermia.