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红细胞生成素(erythmpoietin,EPO)是由肾脏产生的特异性刺激红细胞生成的造血生长因子。近年来的 研究发现EPO不仅仅只作用于造血系统,作为一种多功能的营养因子,它还对整个机体稳态的维持发挥作用。在 中枢神经系统和脑脊液中均发现有特殊的EPO及EPO受体系统,该系统独立于造血系统中的EPO及其受体系统 而存在。EPO在不同种类的神经损伤(如脑缺血、缺氧及蛛网膜下腔出血等)中具有神经营养和保护功能,重组人 红细胞生成素(recombinant human erythropoietin,rhEPO)疗法将很快用于临床实践去修复上述疾病引起的神经损 伤。
Erythropoietin (EPO) is a hematopoietic growth factor produced by the kidneys that specifically stimulates erythropoiesis. Recent studies have found that EPO acts not only on the hematopoietic system but also as a multifunctional trophic factor that also contributes to the maintenance of the overall homeostasis. In the central nervous system and cerebrospinal fluid are found in the special EPO and EPO receptor system, the system independent of the hematopoietic system of EPO and its receptor system exists. EPO has neurotrophic and protective functions in various types of nerve damage such as cerebral ischemia, hypoxia and subarachnoid hemorrhage, and recombinant human erythropoietin (rhEPO) therapy will be rapidly used in clinical practice Practice to repair these diseases caused by nerve damage.