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本文通过免疫细胞化学及体视学定量分析方法,观察89例脾虚证患者胃窦G细胞变化,与空腹血清胃泌素含量进行相关分析。结果发现,脾虚气滞型患者胃窦 G 细胞数密度及空腹血清胃泌素含量明显高于脾胃气虚组和正常对照组(P<0.01~0.001);胃窦 G 细胞数目与空腹血清胃泌素含量呈显著正相关(r=0.40,P<0.01)。提示:胃窦 G 细胞增生及其分泌功能亢进可能是形成脾虚不同证型的病理学机制之一。
In this paper, the quantitative analysis of immunocytochemistry and stereology was used to observe the change of gastric antrum G cells in 89 patients with spleen-deficiency syndrome and to analyze the relationship between fasting serum gastrin content. The results showed that the number density of gastric antrum G and the content of fasting serum gastrin in patients with spleen deficiency and qi stagnation were significantly higher than those in spleen and stomach qi deficiency group and normal control group (P<0.01-0.001); the number of gastric antrum G cells and fasting serum gastrin The content showed a significant positive correlation (r=0.40, P<0.01). Tip: Gastric antral G cell proliferation and hypersecretion may be one of the pathological mechanisms of the formation of different syndromes of spleen deficiency.