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目的:探讨人大肠癌组织中FAP表达与其临床病理特征的关系。方法:采用免疫组化EN法检测1 4 5例大肠癌组织中FAP的表达。结果:FAP半定量计数、表达浓度与肿瘤分期呈正相关(P=0.02,P=0.01),即在临床分期高的肿瘤组织中,FAP表达的量及浓度都显著增高;FAP染色与肿瘤分级之间没有明显的相关性(P>0.05)。结论:FAP高表达可能与大肠癌的浸润生长及转移有密切关系。
Objective: To investigate the relationship between FAP expression and clinicopathological features in colorectal cancer. Methods: The expression of FAP in 145 cases of colorectal carcinoma was detected by immunohistochemistry. Results: FAP expression was positively correlated with the tumor stage (P = 0.02, P = 0.01), indicating that the FAP expression levels and concentrations were significantly increased in the tumor tissues with high clinical stage. FAP staining and tumor grade There was no significant correlation (P> 0.05). Conclusion: The high expression of FAP may be closely related to the invasion and metastasis of colorectal cancer.