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目的 探讨高压氧治疗新生儿缺氧缺血性脑病 (HIE)的远期疗效。 方法 治疗后 4～ 5年对高压氧 (HBO)治疗组 32例 ,对照组 (同期未用HBO治疗者 ) 2 8例进行随访并做详细的体格及神经系统检查 ,观察两组的远期疗效。 结果 治疗组丹佛氏智测异常率低于对照组 (P =0 .0 0 0 3) ,HIE预后不良率亦较对照组降低 (中度 :P =0 .0 2 ;重度 :P =0 .0 1) ,视听检查均无异常发现。 结论 HBO治疗HIE能改善HIE患儿智力发育并降低预后不良率 ,且无减压病及视听异常等副作用发生。
Objective To investigate the long-term effect of hyperbaric oxygen therapy on neonatal hypoxic-ischemic encephalopathy (HIE). Methods Twenty-eight patients in HBO group and 28 in control group (HBO-free group) were followed up 4 to 5 years after the treatment and detailed physical and neurological examinations were performed. The long-term efficacy . Results The abnormal rate of Denver Occlusion in the treatment group was lower than that in the control group (P = 0.00003). The rate of poor prognosis of HIE was also lower than that in the control group (moderate: P = 0.002; severe: P = 0). 0 1), audio-visual examination showed no abnormalities. Conclusion HBO treatment of HIE can improve the mental development of children with HIE and reduce the rate of poor prognosis, and no decompression sickness and audio-visual abnormalities and other side effects occur.