【摘 要】
：
目的研究P-糖蛋白(P-gp)抑制剂维拉帕米对辣椒素经肠黏膜转运时的影响。方法通过体外扩散池的方法,分别用空肠,回肠和结肠黏膜研究辣椒素在吸收和分泌2个方向的透过情况。结
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目的研究P-糖蛋白(P-gp)抑制剂维拉帕米对辣椒素经肠黏膜转运时的影响。方法通过体外扩散池的方法,分别用空肠,回肠和结肠黏膜研究辣椒素在吸收和分泌2个方向的透过情况。结果 P-gp抑制剂维拉帕米对辣椒素经肠黏膜吸收和分泌方向的透过没有影响,并保持着结肠特异性透过的性质。结论本实验通过体外透过证明辣椒素不是P-gp的底物,并且在维拉帕米的存在下,辣椒素仍然具有结肠特异性透过,说明P-gp对于辣椒素的肠道区段性透过影响不大。
Objective To investigate the effect of verapamil, a P-glycoprotein inhibitor, on the transmucosal transport of capsaicin. Methods The diffusion of capsaicin in two directions of absorption and secretion were studied by means of in vitro diffusion cell, using jejunum, ileum and colon mucosa respectively. Results The P-gp inhibitor verapamil had no effect on the absorption and secretion of capsaicin in the intestinal mucosa, and maintained the colon-specific permeability. Conclusions This experiment demonstrated that capsaicin is not a substrate of P-gp by in vitro permeation and that capsaicin still has colon-specific transmission in the presence of verapamil, indicating that P-gp binds to the gut segment of capsaicin Sexually transmitted little effect.
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