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目的:观察中西医结合治疗冷哮型急性支气管哮喘患者的临床疗效。方法:选取100例冷哮型急性支气管哮喘患者,随机分为对照组和研究组各50例。2组均予沙丁胺醇气雾剂、氨茶碱注射液等对症治疗,研究组再予射干麻黄汤加减治疗。观察2组治疗前后症状总积分、超敏C-反应蛋白(hs-CRP)、肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量百分比(FEV_1/FVC%)]的变化及用药安全性。结果:总有效率研究组98.0%,对照组86.0%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组症状总积分及hs-CRP水平均较治疗前降低(P<0.01);研究组症状总积分及hs-CRP水平均低于对照组(P<0.05)。研究组FEV_1、FVC、FEV_1/FVC%值均高于对照组(P<0.05)。2组患者在治疗过程中均未见严重的不良反应事件发生。结论:中西医结合治疗冷哮型急性支气管哮喘患者安全有效,能提高临床疗效,有效改善患者的肺功能。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of cold asthma patients with acute asthma. Methods: A total of 100 patients with cold-swallow acute bronchial asthma were randomly divided into control group and study group (n = 50). 2 groups were given albuterol aerosol, aminophylline injection and other symptomatic treatment, the study group and then injection of dry Mahuang Decoction treatment. The total scores of symptoms, hs-CRP, pulmonary function [FEV1], forced vital capacity (FVC) and forced expiratory volume in 1 second were observed before and after treatment in two groups, Changes in vital capacity (FEV 1 / FVC%)] and medication safety. Results: The total effective rate was 98.0% in the study group and 86.0% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the total score of symptoms and the level of hs-CRP in both groups were lower than those before treatment (P <0.01). The total scores of symptoms and hs-CRP in the study group were lower than those in the control group (P <0.05). The FEV 1, FVC and FEV 1 / FVC% of the study group were higher than those of the control group (P <0.05). Two groups of patients in the course of treatment, no serious adverse events occurred. Conclusion: The combination of TCM and Western medicine is safe and effective in the treatment of patients with cold-swallow acute bronchial asthma, which can improve the clinical curative effect and effectively improve the lung function of patients.