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以ＣＣｌ＿４诱发大鼠肝脏脂质过氧化为自由基损伤模型，观察枸杞多糖（ｌｙｃｉｕｍ ｂａｒｂａｒｕｍｐｃｌｙｓａｃｃｈａｒｉｄｏ，ＬＢＰ）不同剂量（２５ｍｇ／１００ｇＢＷ·ｄ－１；５０ｍｇ／１００ｇＢｗ·ｄ－１）对鼠肝的保护作用。结果低剂量组能明显降低肝中丙二醛（ＭＤＡ）及甘油三脂（ＴＧ）（Ｐ＜０．０１，Ｐ＜０．０５）；两剂量组均能明显升高肝中超氧化物歧化酶（ＳＯＤ）活性（Ｐ＜０．００１）。提示ＬＢＰ对鼠肝自由基损伤有保护作用。高剂量组对ＭＤＡ及ＴＧ降低作用不明显，ＬＢＰ减轻脂质过氧化作用可能存在最佳剂量范围。
The model of rat liver lipid peroxidation induced by CCl_4 was used to observe the protective effects of different doses of lycium barbarum (clavulae) (LBP) (25mg/100gBW·d-1; 50mg/100gBw·d-1) on rat liver. . Results Low-dose group can significantly reduce malondialdehyde (MDA) and triglyceride (TG) in the liver (P<0.01, P<0.05); Both dose groups can significantly increase superoxide dismutase in liver. (SOD) activity (P<0.001). It is suggested that LBP has protective effects on rat liver free radical damage. The lower doses of MDA and TG were not significantly decreased in the high-dose group, and the optimal dose range for LBP to reduce lipid peroxidation was possible.